Related Experiment Video
Updated: Jul 23, 2026

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats
Published on: April 17, 2013
Glomerular basement membrane: lamina rara, lamina densa
Abstract:
Electron immunohistochemical and histochemical studies of glomerular and tubular basement membranes were undertaken to elucidate the relationship between lamina rara and lamina densa. Our results indicate that the lamina rara is not a fixation artifact and it has common antigenic determinants with lamina densa (type IV collagen antigens). Therefore, lamina rara has to be considered an integral component of basement membranes, and biochemical preparations containing only lamina densa should not be considered representative of the whole basement membrane.
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