Plasma luteinizing hormone in ovariectomized rats following pharmacologic manipulation of endogenous brain serotonin

Ovariectomized rats were treated with pharmacologic agents to manipulate endogenous brain serotonin (5-HT). Neither the magnitude nor the timing of luteinizing hormone (LH) pulses in plasma were affected by drug-induced decreases in 5-HT. Acute increases in extraneuronal 5-HT resulting from fluoxetine administration to inhibit 5-HT uptake into neurons, decreased the magnitude of LH pulses, but did not affect the interval between successive LH pulses.