Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interhemispheric differences in photosensitive epilepsy. II. Intermittent photic stimulation.

C D Binnie, A J Wilkins, R A De Korte

    Electroencephalography and Clinical Neurophysiology
    |November 1, 1981
    PubMed
    Summary

    In photosensitive epilepsy patients, asymmetrical discharges were observed unilaterally in over half of individuals. This asymmetry was not linked to clinical signs of brain pathology, suggesting uneven cortical hyperexcitability.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The possible use of precision tinted lenses to improve social cognition in children with autism spectrum disorders.

    Vision research·2020
    Same author

    Chromaticity separation and the alpha response.

    Neuropsychologia·2017
    Same author

    Cortical excitability and the shape of the haemodynamic response.

    NeuroImage·2015
    Same author

    Assessment and selection of candidates for surgical treatment of epilepsy.

    Epilepsia·2012
    Same author

    Electroencephalography today.

    Journal of the Royal Society of Medicine·2010
    Same author

    Spectral filters can improve reading and visual search in patients with multiple sclerosis.

    Journal of neurology·2007

    Area of Science:

    • Neurology
    • Epileptology
    • Neurophysiology

    Background:

    • Photosensitive epilepsy is characterized by seizures triggered by visual stimuli.
    • Cortical hyperexcitability is a proposed mechanism in primary cortico-reticular epilepsy.
    • Previous research indicated asymmetrical pattern sensitivity in these patients.

    Purpose of the Study:

    • To investigate the distribution of asymmetrical discharges in response to intermittent photic stimulation (IPS) in photosensitive epilepsy.
    • To determine if IPS-induced discharge asymmetry correlates with clinical indicators of cerebral pathology.

    Main Methods:

    • Analysis of 138 consecutive photosensitive epilepsy patients.
    • Recording and assessment of electroencephalogram (EEG) responses to intermittent photic stimulation (IPS).

    Related Experiment Videos

  • Statistical analysis to identify unilateral preponderance of asymmetrical discharges and correlate with clinical data.

    • Main Results:

    • 57 out of 138 patients (41%) exhibited a significant unilateral preponderance of asymmetrical discharges on IPS.
    • No significant association was found between the asymmetry of IPS-induced discharges and clinical factors such as partial or secondary generalized epilepsy, neurological deficits, or left-handedness.
    • These findings suggest a non-uniform distribution of cortical hyperexcitability.

    Conclusions:

    • The observed unilateral asymmetry of discharges in photosensitive epilepsy is not explained by clinical cerebral pathology.
    • The results support the hypothesis that cortical hyperexcitability in primary cortico-reticular epilepsy is unevenly distributed across the cortex.
    • Further research is warranted to understand the implications of this asymmetrical hyperexcitability.