Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperreactivity to myelin basic protein in multiple sclerosis.

A E Eggers, L Tarmin, C R Plank

    Journal of the Neurological Sciences
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A chronic dysfunctional stress response can cause stroke by stimulating platelet activation, migraine, and hypertension.

    Medical hypotheses·2005
    Same author

    Neurological theory of hypertension.

    Medical hypotheses·2003
    Same author

    New neural theory of migraine.

    Medical hypotheses·2001
    Same author

    Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines.

    Genes, chromosomes & cancer·1995
    Same author

    Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms.

    Cancer research·1995
    Same author

    Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus.

    Cancer research·1994
    Same journal

    Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

    Journal of the neurological sciences·2026
    Same journal

    Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

    Journal of the neurological sciences·2026
    Same journal

    Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

    Journal of the neurological sciences·2026
    Same journal

    Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

    Journal of the neurological sciences·2026
    Same journal

    Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

    Journal of the neurological sciences·2026
    Same journal

    Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

    Journal of the neurological sciences·2026
    See all related articles

    Multiple sclerosis patients show heightened reactivity to myelin basic protein. This immune response, measured by cell-mediated cytotoxicity, is significantly stronger in MS patients compared to controls, even after immune boosting.

    Area of Science:

    • Neuroimmunology
    • Cellular Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
    • The role of cell-mediated immunity in MS pathogenesis is under investigation.

    Purpose of the Study:

    • To assess cell-mediated cytotoxicity against myelin basic protein (MBP) in multiple sclerosis patients.
    • To compare immune responses in MS patients with those in controls with other neurological diseases and healthy volunteers.

    Main Methods:

    • A short-term 51chromium release assay was employed.
    • Lymphocyte targets were coated with myelin basic protein (MBP).
    • Reactivity was measured before and after in vitro MBP boosting.

    Main Results:

    Related Experiment Videos

  • Multiple sclerosis patients exhibited hyperreactivity to MBP.
  • This hyperreactivity was observed both before and after in vitro MBP boosting.
  • The in vitro boost amplified the observed differences between MS patients and controls.

    • Conclusions:

    • Cell-mediated immunity against myelin basic protein (MBP) is enhanced in multiple sclerosis patients.
    • These findings suggest a potential autoimmune component involving T-cell responses to MBP in MS.
    • The assay can differentiate MS patients from controls based on immune reactivity to MBP.