[Blood plasma kinin system status in mechanical jaundice and means for its correction]

The state of the kinin system in mechanical jaundice and possible ways for its normalization were analysed on the basis of clinico-experimental observations. In 32 patients with postoperative hepatic insufficiency developed against the background of mechanical jaundice a considerable activation of the kinin system was detected which was found to have a direct correlation with the severity of the disease. In experiments on 185 albino rats with model of mechanical jaundice during 40 days a comparative analysis of the state of the kinin system in the initial state, under conditions of hyperbaric oxygenation (HBO) and when using kontrikal and sodium salicylate against the background of HBO was made. The phasic activation of the kinin system was established. The use of HBO was found to maintain the antikinin activity during 30 days of jaundice. The effect of normalization was increased by the simultaneous use of sodium salicylate.