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[Effect of a modified terrilytin on ampicillin pharmacokinetics in experimental peritonitis]

A A Fokin

    Antibiotiki
    |December 1, 1981
    PubMed

    Insights

    Modified terrilytin significantly boosted ampicillin levels in rabbits with experimental peritonitis. This microbial enzyme enhanced antibiotic efficacy in blood and peritoneal fluid, showing potential for improved infection treatment.

    Area of Science:

    • Pharmacology
    • Microbiology
    • Enzymology

    Background:

    • Peritonitis is a serious abdominal infection.
    • Ampicillin is a commonly used antibiotic.
    • Enzyme therapy is an emerging field in medicine.

    Purpose of the Study:

    • To investigate the effect of modified terrilytin on ampicillin pharmacokinetics.
    • To evaluate the efficacy of this enzyme in experimental peritonitis.

    Main Methods:

    • A study was conducted on 16 rabbits with induced peritonitis.
    • Animals received intramuscular injections of ampicillin and modified terrilytin.
    • Ampicillin levels in blood and peritoneal exudate were measured using the agar-diffusion method.

    Main Results:

    • Modified terrilytin increased ampicillin levels by 50-54% in blood and peritoneal exudate.
    • The most significant increase in ampicillin levels was observed 30 minutes after co-administration.
    • Control group showed no such increase.

    Conclusions:

    • Modified terrilytin enhances ampicillin pharmacokinetics in experimental peritonitis.
    • This enzyme may improve the effectiveness of ampicillin in treating abdominal infections.
    • Further research is warranted to explore clinical applications.

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