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Purified human plasma proteins of unknown function.

H G Schwick, H Haupt

    Japanese Journal of Medical Science & Biology
    |October 1, 1981
    PubMed
    Summary

    Advances in protein chemistry reveal over 100 human plasma proteins, with nearly 20 whose functions remain unknown. Future research on their unique structures and levels in patient sera may elucidate their biological roles.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Proteomics

    Background:

    • Human plasma contains over 100 identified proteins.
    • Many plasma proteins have been characterized physicochemically and immunologically before their biological functions were understood.
    • Notable examples include alpha 1-antitrypsin, Cl-inactivator, and alpha 2-macroglobulin.

    Purpose of the Study:

    • To summarize the advancements in understanding human plasma proteins.
    • To highlight proteins with unknown biological functions.
    • To suggest future research directions for elucidating protein functions.

    Main Methods:

    • Development of advanced analytic and preparative techniques in protein chemistry.
    • Application of immunologic techniques for protein determination.
    • Physicochemical characterization of purified plasma proteins.

    Main Results:

    • Knowledge of human plasma protein variety has significantly increased in the last 15 years.
    • Over 100 human plasma proteins are now known, with approximately 20 whose functions are yet to be determined.
    • Proteins like alpha 1-acid glycoprotein and C-reactive protein, as well as newly described ones like histidinerich and leucine-rich alpha 2-glycoproteins, are discussed.

    Conclusions:

    • The chemical structure of some human plasma proteins may offer clues to their function.
    • Quantitative immunologic determination in patient sera is a promising approach to understand protein roles.
    • Further investigation into the structure and levels of these proteins is crucial for advancing biological understanding.

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