Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary alterations in tumor-host relationship.

O Palacios, H Kubinski

    Cancer Letters
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Mice exposed to Ehrlich ascites tumor cells before birth show altered immune responses to the tumor later in life. This altered tumor reactivity is hereditary and passed to offspring.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Laparoscopic Liver Resection: A South American Experience with 2887 Cases.

    World journal of surgery·2020
    Same author

    Dual effects of different selenium species on wheat.

    Plant physiology and biochemistry : PPB·2014
    Same author

    Assessment of polychlorinated dibenzo-p-dioxins and dibenzofurans in sludges according to the European environmental policy.

    Environment international·2007
    Same author

    Priority organic pollutant assessment of sludges for agricultural purposes.

    Chemosphere·2005
    Same author

    Determination of neutron absorbed doses in lithium aluminates.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2003
    Same author

    MTO: the second member of a Drosophila dual copper-thionein system.

    FEBS letters·2002

    Area of Science:

    • Immunology
    • Developmental Biology
    • Oncology

    Background:

    • Ehrlich ascites tumor cells (EATC) are a model for studying tumor-host interactions.
    • Immune responses to tumors can be complex and vary significantly.
    • In utero exposures can have long-lasting effects on immune development and function.

    Purpose of the Study:

    • To investigate the long-term effects of fetal exposure to EATC on adult immune responses.
    • To determine if altered reactivity to EATC is hereditary.

    Main Methods:

    • Mice were indirectly exposed to EATC during fetal development.
    • Control and exposed mice were later injected with EATC intraperitoneally.
    • Immune responses were monitored and compared between groups.

    Related Experiment Videos

    Main Results:

    • Adult mice exposed to EATC in utero exhibited significantly altered immune responses compared to control mice.
    • Specific aspects of the early immune reaction (48-72 h post-injection) were absent in prenatally exposed animals.
    • The observed altered reactivity was found to be hereditary.

    Conclusions:

    • Fetal exposure to EATC can lead to measurable, long-lasting alterations in immune responses to this tumor.
    • These alterations are heritable, suggesting a potential epigenetic or genetic component.
    • The findings provide insights into developmental immunomodulation and its impact on cancer immunity.