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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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The ABO Blood Group01:12

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
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Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

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Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
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Related Experiment Video

Updated: Apr 26, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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Blue dextran-mediated hemagglutination.

K Imanishi, I Suzuki

    Journal of Immunological Methods
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Blue dextran effectively agglutinated erythrocytes from multiple species at low concentrations. Agglutination was inhibited by calf serum, bovine albumin, and sodium thiocyanate, indicating specific molecular interactions.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Cell Biology

    Background:

    • Erythrocyte agglutination is a key phenomenon in immunology and diagnostics.
    • Understanding the molecular mechanisms of agglutination is crucial for various biological applications.

    Purpose of the Study:

    • To investigate the agglutinating properties of blue dextran on erythrocytes.
    • To identify substances that can inhibit blue dextran-induced erythrocyte agglutination.

    Main Methods:

    • Testing blue dextran at concentrations of 0.1-1 ng/ml.
    • Assessing agglutination of human, mouse, rabbit, and rat erythrocytes.
    • Evaluating the inhibitory effects of calf serum, bovine albumin, sodium thiocyanate, potassium chloride, and magnesium sulfate.

    Main Results:

    • Blue dextran induced agglutination in erythrocytes from all tested species.
    • Agglutination was significantly inhibited by 10% calf serum, 0.5 mg/ml bovine albumin, and 0.2 M sodium thiocyanate.
    • Inhibition was less effective with 1.5 M potassium chloride and absent with 30-50 mM magnesium sulfate.

    Conclusions:

    • Blue dextran acts as an agglutinating agent for mammalian erythrocytes.
    • Specific biomolecules and salts interfere with blue dextran-mediated erythrocyte aggregation, suggesting defined binding mechanisms.