Achylia and the development of gastric carcinoids

Twenty-four patients with gastric carcinoids were examined retrospectively with regard to the presence of achylia and pernicious anaemia (PA). Six patients (25%) had achylia preoperatively and half of these had an associated PA. The gastric carcinoids occurring in an achylic stomach were almost exclusively located to the corpus area and tended to be multiple. Further, the majority of cells in most of them were argyrophil (Sevier-Munger) positive, indicating that they were of the enterochromaffin-like cell type. At present, achylia with or without concomitant PA appears to be the most distinct condition associated with gastric carcinoids. The pathogenesis of these tumours which develop in an achylic stomach is discussed.