Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-associated C-cell hyperplasia in the human thyroid.

W G Gibson, T C Peng, B P Croker

    The American Journal of Pathology
    |March 1, 1982
    PubMed
    Summary

    Thyroid C-cell numbers increase with age, particularly in males. This age-related C-cell hyperplasia is a normal finding and important for diagnosing thyroid conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Quantitative relations between transient BOLD responses, cortical energetics, and impulse firing in different cortical regions.

    Journal of neurophysiology·2019
    Same author

    Quantitative relations between BOLD responses, cortical energetics, and impulse firing.

    Journal of neurophysiology·2017
    Same author

    The combination of two Sle2 lupus-susceptibility loci and Cdkn2c deficiency leads to T-cell-mediated pathology in B6.Fas(lpr) mice.

    Genes and immunity·2013
    Same author

    Antibacterial silver-containing silica glass prepared by ion implantation.

    Journal of nanoscience and nanotechnology·2010
    Same author

    Synthesis and Magnetic Properties of Maghemite (gamma-Fe(2)O(3)) Short-Nanotubes.

    Nanoscale research letters·2010
    Same author

    Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.

    Genes and immunity·2010

    Area of Science:

    • Endocrinology
    • Histology
    • Forensic Pathology

    Background:

    • C cells, responsible for calcitonin production, are found in the human thyroid.
    • Understanding C-cell distribution and quantity is crucial for thyroid pathology diagnosis.

    Purpose of the Study:

    • To quantify C-cell concentrations and numbers in normal human thyroid glands.
    • To investigate the relationship between C-cell density, age, and sex.

    Main Methods:

    • Immunoperoxidase staining for calcitonin was used to identify C cells.
    • Morphometric techniques were employed to determine C-cell concentrations and total numbers.
    • 26 normal human thyroids from forensic autopsies were analyzed.

    Main Results:

    • Significant variation in C-cell density was observed within and among individuals.
    • C cells showed a tendency to aggregate in the upper half of the lateral thyroid lobes.
    • C-cell densities ranged from 1-2000 cells/cu mm in individuals aged 30 and older.
    • A statistically significant positive correlation was found between total C-cell numbers and age in males (P < 0.01).

    Conclusions:

    • C-cell hyperplasia is an age-related phenomenon in normal human thyroids.
    • Findings suggest that increased C-cell numbers with age may have physiological significance.
    • These age-related changes must be considered when evaluating thyroid glands for premalignant C-cell lesions.

    Related Experiment Videos