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Sequential activation in V genes during postnatal life.

C A Bona

    American Journal of Reproductive Immunology : AJRI : Official Journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction
    |January 1, 1980
    PubMed
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    BALB/c mice show sequential V gene activation during development. Different antibody responses emerge at specific ages, indicating a programmed developmental timeline for immune gene expression.

    Area of Science:

    • Immunology
    • Developmental Biology
    • Genetics

    Background:

    • The BALB/c mouse strain is a valuable model for V gene activation studies.
    • Many myeloma proteins share cross-reactive idiotypes with antipolysaccharide antibodies.
    • Antipolysaccharide antibody responses are often T cell-independent, simplifying study.

    Purpose of the Study:

    • To investigate the sequential activation of V genes during postnatal development in BALB/c mice.
    • To determine age-dependent antibody responses to various antigens.

    Main Methods:

    • Immunization of mice at different ages (1-day, 6-8 days, 2 weeks, 4 weeks, 3 months) with specific antigens.
    • Analysis of elicited antibody responses, including idiotype expression.

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    Main Results:

    • 1-day-old mice: anti-β-2,6 fructosan, anti-S. tranaroa LPS, antigalactan responses.
    • 6-8 day-old mice: phosphocholine, anti-Ars, anti-TNP responses.
    • 2-week-old mice: anti-SSSIII, antiflagellin responses.
    • 4-week-old mice: anti-β-2,1 fructosan response.
    • 3-month-old mice: anti-α-1,6 dextran response.

    Conclusions:

    • Observations suggest a distinct, sequential pattern of V gene activation throughout postnatal development in BALB/c mice.
    • This age-dependent immune gene expression has significant theoretical and practical implications for immunology research.