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Cholinergic modulation of substance P release.

B M Jaffe, B Akande, I M Modlin

    Digestive Diseases and Sciences
    |January 1, 1982
    PubMed
    Summary
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    Cholinergic pathways control the release of substance P into the bloodstream. Blocking these pathways with atropine significantly reduced substance P levels after a high-protein meal or bombesin infusion in dogs.

    Area of Science:

    • Neuroendocrinology
    • Gastrointestinal Physiology

    Background:

    • Substance P is a neuropeptide involved in various physiological processes, including gastrointestinal function.
    • Understanding the regulation of substance P release is crucial for comprehending its role in the body.

    Purpose of the Study:

    • To investigate the mechanisms controlling the release of immunoreactive substance P into peripheral circulation.
    • To determine if cholinergic pathways modulate substance P release.

    Main Methods:

    • Experiments were conducted on conscious dogs.
    • Plasma concentrations of immunoreactive substance P were measured after a high-protein meal and bombesin infusion.
    • The effects of atropine, a cholinergic antagonist, on substance P levels were evaluated.

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    Main Results:

    • A high-protein meal significantly increased plasma substance P levels.
    • Prior administration of atropine abolished the substance P response to both the high-protein meal and bombesin infusion.
    • Bombesin infusion alone significantly elevated substance P levels, an effect blocked by atropine.

    Conclusions:

    • The findings strongly suggest that substance P release into the peripheral circulation is under significant cholinergic control.
    • Cholinergic mechanisms play a key role in modulating substance P release in response to physiological stimuli.