Biochemical correlates of illness and recovery in Reye's syndrome

Eight patients with Reye's syndrome were followed through the course of their disease with serial measurements of serum concentrations of ammonia, short-chain organic acids, and amino acids. Correlations were made between clinical status and biochemical alterations. Elevated short-chain fatty acids, hyperammonemia, and hyperaminoacidemia were found in all patients studied. Clinical improvement appeared to correlate most closely with clearance of short-chain fatty acids from the serum. These observations suggest that the clinical symptoms are at least in part related to organic acidemia and that treatment directed toward the rapid clearance of these compounds from the system is reasonable.