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Rabies: recent advances in pathogenesis and control.

A Miller, N Nathanson

    Annals of Neurology
    |December 1, 1977
    PubMed
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    Recent advancements in rabies research cover virology, immunology, and pathogenesis. New vaccines and oral immunization strategies offer improved prevention and control of this viral infection.

    Area of Science:

    • Virology and Immunology
    • Infectious Disease Epidemiology
    • Public Health

    Background:

    • Rabies remains a significant public health concern, particularly due to its enzootic presence in wildlife populations.
    • An estimated 30,000 potential human exposures requiring post-exposure prophylaxis occur annually in the United States.
    • Rabies virus (a rhabdovirus) has a well-described molecular structure and replication cycle.

    Purpose of the Study:

    • To review current knowledge and recent developments in rabies.
    • To highlight advances in understanding rabies virology, immunology, pathogenesis, and prophylaxis.
    • To summarize current treatment recommendations and novel control strategies.

    Main Methods:

    • Review of current scientific literature on rabies.

    Related Experiment Videos

  • Analysis of recent developments in diagnostic techniques for antirabies antibodies and cellular immune responses.
  • Examination of new vaccine technologies and epidemiological data.

    • Main Results:

    • Significant progress has been made in understanding rabies virus replication and host immune responses.
    • New diagnostic tools for measuring antirabies antibodies and cellular immunity have been developed.
    • A highly potent new rabies vaccine for pre- and post-exposure immunization is nearing licensure.
    • Evidence suggests novel approaches, including oral immunization, for wildlife rabies control.

    Conclusions:

    • Recent research has enhanced our understanding of rabies pathogenesis and improved diagnostic capabilities.
    • New vaccine developments promise more effective pre- and post-exposure prophylaxis for rabies.
    • Oral immunization presents a promising strategy for the future control of wildlife rabies.