Langerhans cells among bile duct epithelial cells in chronic liver disease

Langerhans cells were found among bile duct epithelial cells in a biopsy specimen from a patient with chronic liver disease showing cholangitic features. The bile duct was 90 micrometers in diameter and surrounded with mononuclear cell infiltration. Under the electron microscope, the cell had a clear cytoplasm and contained a deeply indented nucleus, a centriole, well-developed Golgi complexes and many rod-shaped bodies (Birbeck granules).