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Physiological responses to spirometer load.

R E Schuhmann, S K Coles, H E Hoff

    Archives Internationales De Physiologie Et De Biochimie
    |December 1, 1981
    PubMed
    Summary
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    Spirometry equipment can temporarily increase breathing rate and tidal volume in cats. This loading effect, driven by reflexes and CO2, highlights how even small changes impact respiratory control.

    Area of Science:

    • * Physiology
    • * Respiratory System Dynamics
    • * Animal Models in Research

    Background:

    • * The spirometric loading effect, a transient increase in respiratory parameters, is a known phenomenon.
    • * Understanding these effects is crucial for accurate physiological measurements and interpreting respiratory control mechanisms.

    Purpose of the Study:

    • * To quantify the transient effects of spirometry on tidal volume and respiratory rate in decerebrate cats.
    • * To investigate the underlying mechanisms, including reflex and chemical factors, contributing to these changes.
    • * To observe the impact of spirometry on different breathing patterns.

    Main Methods:

    • * Experiments conducted on 22 decerebrate cats.
    • * Respiration monitored using impedance pneumography.

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  • * Tidal volume measured using a spirometer at 10-60 minute intervals; 233 spirograms recorded.

    • Main Results:

    • * Significant time-dependent increases in tidal volume (up to 64%) and respiratory rate observed.
    • * Instantaneous minute volumes increased up to nearly 400% of control levels.
    • * Spirometric loading led to regularization of irregular or periodic breathing patterns (e.g., Biot's breathing).

    Conclusions:

    • * Spirometry introduces transient perturbations into the respiratory control system.
    • * Maximal effects are reached within 80 seconds, involving a combination of vagal afferent reflexes and chemical factors (increased CO2).
    • * These findings underscore the importance of considering spirometer-induced effects in respiratory research.