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Related Experiment Videos

Mass transfer in membrane plasma exchange.

D H Randerson, M Blumenstein, R Habersetzer

    Artificial Organs
    |February 1, 1982
    PubMed
    Summary
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    This study evaluated protein removal by three plasma separation devices. All devices showed similar efficacy, but prolonged treatments decreased effectiveness and increased costs.

    Area of Science:

    • Biomedical Engineering
    • Renal Physiology

    Background:

    • Plasma separation devices are crucial for removing solutes from blood.
    • Understanding membrane performance is key to optimizing therapeutic efficiency.

    Purpose of the Study:

    • To determine in vitro and in vivo sieving coefficients (SC) for various proteins across three commercial plasma separation devices.
    • To develop and validate a model predicting solute removal efficiency based on SC and treatment parameters.

    Main Methods:

    • Measured sieving coefficients for proteins (albumin to beta-lipoprotein) using Plasmaflo 0.1, Plasmaflo 02, and Plasmaflux devices.
    • Utilized a mathematical model incorporating pretherapy levels, plasma volume, filtration rate, SC, and treatment duration.
    • Compared model predictions with clinically observed reductions in serum solute levels.

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    Main Results:

    • All three plasma separators demonstrated comparable therapeutic capabilities.
    • The developed model accurately predicted clinical outcomes, validating its utility.
    • Prolonged treatment durations were found to decrease removal effectiveness and increase cost per unit of solute removed.

    Conclusions:

    • Plasma separation devices Plasmaflo 0.1, Plasmaflo 02, and Plasmaflux offer similar clinical performance.
    • Treatment duration significantly impacts the cost-effectiveness and efficiency of plasma separation therapy.
    • The predictive model provides valuable insights for optimizing plasma separation protocols.