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Rheological and clotting changes in chronic cor pulmonale
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1981
Summary
This study on chronic cor pulmonale found higher blood viscosity and lower clotting factors like plasminogen and antithrombin III in patients with acute dyspnea. These changes suggest clotting issues are common in this condition.
Area of Science:
- Cardiology
- Hematology
- Pulmonology
Background:
- Chronic cor pulmonale is a significant health concern.
- Acute dyspnea is a common complication requiring hospitalization.
Purpose of the Study:
- To investigate blood rheology and coagulation changes in patients with chronic cor pulmonale experiencing acute dyspnea.
Main Methods:
- Studied 53 hospitalized patients with chronic cor pulmonale and acute dyspnea.
- Analyzed blood viscosity, plasma viscosity, hematocrit, total plasma proteins, fibrinogen, plasminogen, antithrombin III, and plasma euglobulin lysis time.
Main Results:
- Elevated blood and plasma viscosities were observed.
- Significantly lower levels of plasminogen and antithrombin III were found.
- Shortened plasma euglobulin lysis time and normal/near-normal fibrinogen levels were noted.
Conclusions:
- Altered pulmonary rheology may facilitate clotting changes in chronic cor pulmonale.
- Coagulation abnormalities are frequently present in this patient group.
- Findings highlight the link between rheological and hemostatic alterations.