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Related Experiment Videos

Combined light and electron microscope in routine histopathology.

S Jones, S K Chapman, P R Crocker

    Journal of Clinical Pathology
    |April 1, 1982
    PubMed
    Summary

    The new light and electron microscope (LEM 2000) improves surgical histopathology by reducing sampling errors. Its features facilitate easier identification of diagnostically important areas in tissue samples.

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    Area of Science:

    • Pathology
    • Microscopy
    • Histopathology

    Background:

    • Routine surgical histopathology relies on accurate microscopic examination of tissue samples.
    • Conventional microscopy techniques can be time-consuming and prone to sampling errors.

    Purpose of the Study:

    • To evaluate the utility of a prototype combined light and electron microscope (LEM 2000) for routine surgical histopathology.
    • To assess the advantages of the LEM 2000 over conventional transmission electron microscopies.

    Main Methods:

    • Experience with the prototype LEM 2000 was reported.
    • The microscope's features, including large grid size, low magnification, and built-in microprocessor, were assessed.

    Main Results:

    • The LEM 2000 offers advantages for surgical histopathology.

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  • Key benefits include a large grid size (7 mm diameter) and low magnification (x 250).
  • A built-in microprocessor aids in recording areas of interest, reducing sampling errors and improving orientation.

    • Conclusions:

    • The LEM 2000 facilitates orientation and relocation of diagnostically important fields.
    • This prototype demonstrates potential for enhancing routine surgical histopathology workflows.