Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple postsynaptic dopamine receptors and behavioral manifestation.

N Fujita, A Hirata, K Saito

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1982
    PubMed
    Summary

    Lisuride hydrogen maleate (LHM) acts on distinct dopamine receptors. Non-cooperative dopamine receptors mediate turning behavior, while cooperative receptors are involved in stereotypy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Modulation of pain perception through transcranial alternating current stimulation and its nonlinear relationship with the simulated electric field magnitude.

    European journal of pain (London, England)·2024
    Same author

    Effect of baseline urinary glucose levels on the relationship between sodium-glucose cotransporter 2 inhibitors and serum uric acid in Japanese patients with type 2 diabetes mellitus.

    Die Pharmazie·2024
    Same author

    Predicting habitual water intake from lifestyle questions.

    European review for medical and pharmacological sciences·2023
    Same author

    Time-dependent changes in serum magnesium levels in patients receiving cetuximab with low baseline serum sodium levels.

    Die Pharmazie·2022
    Same author

    Metallic Glacial Glass Formation by a First-Order Liquid-Liquid Transition.

    The journal of physical chemistry letters·2020
    Same author

    Hepatobiliary and Pancreatic: Intrahepatic cholangiocarcinoma with intratumoral calcification mimicking hepatolithiasis.

    Journal of gastroenterology and hepatology·2019

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Previously identified non-cooperative and positive-cooperative dopamine receptors in rat striatum.
    • Non-cooperative sites are sulpiride-sensitive, while cooperative sites are not.

    Purpose of the Study:

    • Investigate the involvement of these two postsynaptic dopamine receptor types in behavioral manifestations.
    • Utilize lisuride hydrogen maleate (LHM) to differentiate receptor actions.

    Main Methods:

    • Administered LHM to rats with unilateral striatal lesions (6-hydroxydopamine or kainic acid).
    • Observed turning behavior following LHM administration.
    • Investigated the effect of sulpiride pretreatment on LHM-induced behaviors.
    • Examined LHM's effect on apomorphine-induced stereotyped behavior.

    Related Experiment Videos

    Main Results:

    • LHM induced contralateral turnings in 6-hydroxydopamine lesioned rats.
    • LHM caused ipsilateral turnings in kainic acid lesioned rats, similar to apomorphine.
    • Sulpiride pretreatment abolished LHM's effect on rotating behavior.
    • LHM inhibited apomorphine-induced stereotyped behavior, an effect not blocked by sulpiride.

    Conclusions:

    • Lisuride hydrogen maleate exhibits dual action on multiple postsynaptic dopamine receptors.
    • Non-cooperative postsynaptic dopamine receptors are implicated in rotating behavior.
    • Cooperative postsynaptic dopamine receptors are involved in the elicitation of stereotypy.