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[Alpha 2-antiplasmin in childhood].
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1982
Summary
Alpha 2-antiplasmin levels increase in newborns with sepsis, acting as an acute phase reactant. Lower levels indicate poor prognosis, suggesting diagnostic value in pediatric sepsis and related conditions.
Area of Science:
- Biochemistry
- Pediatric Medicine
- Hematology
Background:
- Alpha 2-antiplasmin is a key inhibitor in the fibrinolytic system.
- Its role in neonatal sepsis and related conditions requires further elucidation.
Purpose of the Study:
- To investigate alpha 2-antiplasmin levels in pediatric patients, particularly newborns with sepsis.
- To assess the diagnostic utility of alpha 2-antiplasmin as an acute phase reactant.
Main Methods:
- Chromogenic substrate S-2251 was used to determine alpha 2-antiplasmin levels in 119 children.
- Measurements were compared between healthy newborns, septic infants, and those with other conditions like respiratory distress.
Main Results:
- Healthy newborns had 65% of adult alpha 2-antiplasmin levels.
- Septic infants showed elevated alpha 2-antiplasmin, increasing during the sepsis course.
- Alpha 2-antiplasmin correlated with fibrin binding and acted as an acute phase reactant.
- Lower levels were observed in patients with shock or declining health.
- Reduced levels were noted in respiratory distress and non-septic disseminated intravascular coagulation.
Conclusions:
- Alpha 2-antiplasmin is a valuable acute phase reactant in pediatric sepsis.
- Its levels provide diagnostic insights into sepsis, disseminated intravascular coagulation, and other critical conditions.
- Monitoring alpha 2-antiplasmin may aid in assessing disease severity and prognosis in neonates and infants.