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Related Experiment Videos

Interferon induction by measles virus.

J L McKimm-Breschkin, F Rapp

    Intervirology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Measles virus interferon induction varies by cell type and passage history. The interferon-inducing (IF+) phenotype is unstable in vivo, while the noninducing (IF-) phenotype is stable, indicating complex virus-host interactions.

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    Area of Science:

    • Virology
    • Immunology
    • Cell Biology

    Background:

    • Measles virus exhibits variability in its ability to induce interferon (IFN).
    • Previous studies identified measles virus isolates as either interferon-inducing (IF+) or interferon-noninducing (IF-).

    Purpose of the Study:

    • To investigate the factors influencing interferon induction by measles virus isolates in different cell types.
    • To understand the stability and regulation of the interferon-inducing phenotype in vitro and in vivo.

    Main Methods:

    • Studied interferon induction in BSC-1 cells and other cell types using IF+ and IF- measles virus isolates.
    • Assessed the presence of inhibitory factors by co-infecting cells with both IF+ and IF- stocks.
    • Evaluated the influence of virus genome, cell type, and passage history on IFN induction.

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  • Compared in vitro and in vivo stability of the IF+ and IF- phenotypes.

    • Main Results:

    • Lack of IFN induction by IF- viruses was not due to inhibitory factors.
    • Interferon induction phenotype expression was dependent on infectious virus genome, cell type, and passage history.
    • In vivo, the IF- phenotype was stable, while the IF+ phenotype was selected against during passage.

    Conclusions:

    • Phenotypic expression of measles virus interferon induction is complex.
    • Interactions between virus and host cell factors in vitro and in vivo regulate IFN induction.