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Related Experiment Videos

The peripheral substance P-ergic system.

J M Polak, S R Bloom

    Peptides
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Substance P, a key peptide, is distributed throughout the nervous system and peripheral organs. It plays a crucial role in sensory transmission and regulating smooth muscle and blood vessels.

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    Area of Science:

    • Neuroscience
    • Peptide Research
    • Cell Biology

    Background:

    • Substance P is a neuropeptide involved in various physiological processes.
    • Its distribution and function in the central and peripheral nervous systems are of significant interest.
    • Understanding Substance P's characteristics is vital for neurological and physiological research.

    Purpose of the Study:

    • To review the distribution, quantity, and physico-chemical properties of Substance P.
    • To elucidate the role of Substance P as a sensory transmitter and modulator of physiological functions.
    • To characterize the ultrastructural localization of Substance P within neurosecretory vesicles.

    Main Methods:

    • Comprehensive literature review on Substance P distribution and characteristics.

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  • Immunocytochemical analysis using gold-labelled antibodies on ultrathin sections.
  • Experimental validation through nerve ligation, ganglion destruction, and capsaicin treatment.

    • Main Results:

    • Substance P is found in the central nervous system and seven peripheral organs.
    • Nerve fibers containing Substance P are closely associated with smooth muscle and blood vessels.
    • Significant concentrations of Substance P were detected in primary sensory neurons and their branches, with depletion observed after experimental interventions.
    • Ultrastructural analysis revealed Substance P within a specific subclass of large, dense, p-type neurosecretory vesicles (mean size 85 +/- 15 nm).

    Conclusions:

    • Substance P is widely distributed and plays a significant role in sensory neurotransmission.
    • Its presence near smooth muscle and blood vessels supports its function in modulating vascular tone and smooth muscle activity.
    • The ultrastructural findings provide precise localization of Substance P within specific neurosecretory vesicles, advancing our understanding of its storage and release mechanisms.