[Radioimmunological analysis of simian adenovirus SA7 hexon]

Direct and competitive radioimmunoassay (RIA) identified several antigenic determinants in hexone of adenovirus (Ad) of lower primates SA7: a species-specific, one common for Ad SA7 and SV38, as well as 2 genus-specific determinants: one common for the studied human Ad types 1 and 6, simian Ad SA7 and SV38, cattle AD of type 3, and a new determinant common for human Ad type 6 and simian Ad SA7 and SV38. It is proposed that the above genus specific determinants be designated alpha 1 and alpha 2, respectively. Indirect evidence of the occurrence in nature of rabbit Ad was obtained as sera from some nonimmunized animals precipitate purified labeled SA7 hexone, i.e. contain antibodies to the genus-specific determinant of the hexone.