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Regulatory function of Thy1-negative cells. I.--Evidence for cells without the Thy1-surface marker and without
Dextran-activated Thy1-cells are effective in enhancing the IgM anti-body response of syngeneic and allogeneic spleen cells to an unrelated antigen. This regulatory activity is mediated through a soluble B-cell-enhancing factor (BEF) which is released by activated cells. Removal of macrophages by silica-treatment does not abolish the regulatory activity of remaining cells. BEF can be considered as an auxiliary factor which does not substitute for either T cells or macrophages in in vitro antibody production.
Dextran-activated Thy1-cells are effective in enhancing the IgM anti-body response of syngeneic and allogeneic spleen cells to an unrelated antigen. This regulatory activity is mediated through a soluble B-cell-enhancing factor (BEF) which is released by activated cells. Removal of macrophages by silica-treatment does not abolish the regulatory activity of remaining cells. BEF can be considered as an auxiliary factor which does not substitute for either T cells or macrophages in in vitro antibody production.