Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of immunoglobulin G-Fc receptor-bearing T lymphocytes in Graves' disease.

H Mori, N Amino, Y Iwatani

    The Journal of Clinical Endocrinology and Metabolism
    |September 1, 1982
    PubMed
    Summary

    Peripheral immunoglobulin G (IgG)-Fc receptor-bearing T lymphocytes (T gamma cells) are decreased in active Graves' disease, correlating inversely with thyroid hormone levels. This finding may contribute to the persistence of thyrotoxicosis in Graves' disease patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [The effectiveness of radiotherapy for Merkel cell carcinoma].

    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
    Same author

    Performance of an enzyme-linked immunosorbent assay system for antibodies to hepatitis C virus with two new antigens (c11/c7).

    Clinical chemistry·1992
    Same author

    [Effect of suplatast tosilate (IPD-1151T) on types I-IV allergic reactions].

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica·1992
    Same author

    [The first cholera case diagnosed early in the clinical laboratory by DNA probe method].

    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·1992
    Same author

    Extra-adrenal pheochromocytoma-ganglioneuroma. A case report.

    Pathology, research and practice·1992
    Same author

    [Effects of suplatast tosilate (IPD-1151T) on antibody formations in mice].

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica·1992

    Area of Science:

    • Immunology
    • Endocrinology
    • Thyroid Research

    Background:

    • Autoimmune thyroid diseases (AITD) involve complex immune dysregulation.
    • Peripheral immunoglobulin G (IgG)-Fc receptor-bearing T lymphocytes (T gamma cells) play a role in immune responses.
    • Understanding T gamma cell dynamics is crucial for AITD pathogenesis.

    Purpose of the Study:

    • To quantify T gamma cell percentages in patients with AITD and destruction-induced thyrotoxicosis.
    • To investigate the relationship between T gamma cell levels and thyroid hormone status.
    • To explore the potential role of T gamma cells in the perpetuation of thyrotoxicosis in Graves' disease.

    Main Methods:

    • Assay of peripheral T gamma lymphocytes using erythrocyte antibody-rosette formation.

    Related Experiment Videos

  • Microplate technique employed for T gamma cell measurement.
  • Comparison of T gamma cell percentages between patient groups and normal controls.

    • Main Results:

    • Significantly lower T gamma cell percentages were observed in untreated and treated thyrotoxic Graves' disease patients compared to normal controls.
    • Normal T gamma cell percentages were found in euthyroid Graves' disease patients and in patients with Hashimoto's disease and destruction-induced thyrotoxicosis.
    • Inverse correlation found between T gamma cell percentage and serum thyroid hormone levels (T4, free T4 index, T3, free T3 index) in autoimmune thyroid diseases (excluding Hashimoto's with destructive thyrotoxicosis).

    Conclusions:

    • A decreased proportion of T gamma lymphocytes is characteristic of active Graves' disease, particularly in the thyrotoxic phase.
    • The reduction in T gamma cells correlates with elevated thyroid hormone levels, suggesting a link to disease activity.
    • The diminished T gamma cell presence may be implicated in the ongoing thyrotoxicosis observed in Graves' disease.