Related Experiment Video
Updated: Aug 9, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Relative AV-insufficiency--morphometric and morphologic investigation of the AV-valve apparatus
Abstract:
Circumference and surface area of AV-valves were determined in 200 hearts formalin-fixed in their postmortem contracted state. It was found that, with increasing ventricular weight, the increase of the surface area of the valves exceeds that of the valve circumference. According to our findings, it is unlikely that relative valvular incompetence in eccentric cardiac hypertrophy is solely due to a disproportion between the valve surface area and circumference. Degenerative vascular changes of papillary muscle arteries and fibrosis of the papillary muscles may play one etiological role in the relative insufficiency of these valves.
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Aortic Regurgitation II: Clinical Features and Diagnostic Tests

