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Related Experiment Videos

Ketoconazole in Trichophyton rubrum.

G Laurberg

    Acta Dermato-Venereologica
    |January 1, 1982
    PubMed
    Summary

    Ketoconazole effectively treated T. rubrum skin infections in 60% of patients. However, nail infections remained uncured, and recurrences were noted, suggesting longer treatment durations for resistant fungal infections.

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    Area of Science:

    • Dermatology
    • Mycology
    • Infectious Diseases

    Background:

    • Tinea rubrum infections can be challenging to treat, often requiring multiple therapeutic approaches.
    • Previous treatments with Griseofulvin and topical antifungals were ineffective in these patients.
    • Ketoconazole is an imidazole antifungal agent used for various fungal infections.

    Purpose of the Study:

    • To evaluate the efficacy of Ketoconazole in patients with T. rubrum infections resistant to standard treatments.
    • To assess the clinical and mycological outcomes of Ketoconazole therapy for skin and nail infections.

    Main Methods:

    • Ten patients with confirmed T. rubrum infections received Ketoconazole (200-400 mg/day) for 8 weeks.
    • Infections included skin lesions and, in two cases, concurrent toe nail involvement.
    • Clinical assessment and mycological examinations were performed to evaluate treatment response.

    Main Results:

    • Complete resolution of skin lesions was observed in 6 out of 10 patients.
    • No improvement was noted in the toe nail infections.
    • Recurrence of skin infection occurred in 3 of the 6 successfully treated patients within 2 months post-treatment.

    Conclusions:

    • Ketoconazole shows partial efficacy against T. rubrum skin infections, particularly in cases resistant to other therapies.
    • The drug was ineffective for T. rubrum nail infections.
    • Extended treatment duration beyond 8 weeks may be necessary to prevent recurrence in resistant T. rubrum infections.

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