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Modifications of the biological activity of anti-D immunoglobulin caused by heat aggregation
Some of the biological activities known to be confined to certain anti-D sera such as Ripley could be simulated using heat-treated human anti-D Ig preparations. Thus, human red cells sensitized with heat-treated anti-D Ig were found to be capable of causing Fc-receptor on lymphocyte surfaces and of fixing complement. In its other effects such as reactivity to rheumatoid factor and to anti-allotype agglutinators, heat-treated anti-D Ig seemed inferior to such anti-D sera as Ripley.
Some of the biological activities known to be confined to certain anti-D sera such as Ripley could be simulated using heat-treated human anti-D Ig preparations. Thus, human red cells sensitized with heat-treated anti-D Ig were found to be capable of causing Fc-receptor on lymphocyte surfaces and of fixing complement. In its other effects such as reactivity to rheumatoid factor and to anti-allotype agglutinators, heat-treated anti-D Ig seemed inferior to such anti-D sera as Ripley.