Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell lines derived from teratocarcinomas.

J F Nicolas, P Avner, J Gaillard

    Cancer Research
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A regional strategy to decrease the time to thrombectomy in patients with low probability of treatment by thrombolysis.

    Revue neurologique·2021
    Same author

    Fusion Imaging Reduces Radiation and Contrast Medium Exposure During Endovascular Revascularization of Iliac Steno-Occlusive Disease.

    Cardiovascular and interventional radiology·2019
    Same author

    Genotypic and phenotypic diversity of Lactobacillus rossiae isolated from beer.

    Journal of applied microbiology·2019
    Same author

    Histidine metabolism after Bretschneider cardioplegia in cardiac surgical patients.

    Physiological research·2018
    Same author

    Endovascular stent-based revascularization of malignant superior vena cava syndrome with concomitant implantation of a port device using a dual venous approach.

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2017
    Same author

    Letrozole may be a valuable maintenance treatment in high-grade serous ovarian cancer patients.

    Gynecologic oncology·2017
    Same journal

    CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.

    Cancer research·2026
    Same journal

    A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

    Cancer research·2026
    Same journal

    Editor's Note: Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib.

    Cancer research·2026
    Same journal

    Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

    Cancer research·2026
    Same journal

    Retraction: Two Functional Epitopes of Pigment Epithelial-Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer.

    Cancer research·2026
    Same journal

    Editor's Note: Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

    Cancer research·2026
    See all related articles

    Researchers isolated embryonal carcinoma (EC) cell lines from teratocarcinomas, revealing variants crucial for studying mouse development and differentiation. These EC cells mimic stem cells, offering insights into tissue formation and tumorigenesis.

    Area of Science:

    • Developmental Biology
    • Cancer Research
    • Cell Biology

    Background:

    • Teratocarcinomas contain malignant embryonal carcinoma (EC) cells, which are stem cells responsible for tumor differentiation.
    • EC cells share properties with multipotential embryonic cells, making them valuable research models.

    Purpose of the Study:

    • To isolate and characterize cell lines from transplantable teratocarcinomas.
    • To investigate the differentiation potential and tumorigenicity of EC cell variants.
    • To establish a resource for studying mouse development and differentiation.

    Main Methods:

    • Isolation of cell lines in vitro from transplantable teratocarcinomas.
    • In vivo and in vitro isolation of variants from established EC cell lines.
    • Characterization of EC cell variants based on differentiation patterns, tumorigenicity, and antigenic properties.

    Related Experiment Videos

    Main Results:

    • Successfully isolated multiple EC cell lines, some exhibiting restricted differentiation.
    • Generated variants with altered tumorigenicity and antigenic characteristics.
    • Identified novel tumoral lines derived from extra-embryonic tissues.

    Conclusions:

    • EC cell lines derived from teratocarcinomas are valuable models for studying stem cell biology.
    • EC cell variants provide insights into developmental pathways and tumorigenesis.
    • These cell lines offer a versatile system for investigating mouse embryonic development and differentiation processes.