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Related Experiment Videos

Platelet activation during exercise-induced myocardial ischaemia.

A S Hughes, C D Ilsley, L Wilkinson

    Thrombosis Research
    |June 15, 1982
    PubMed
    Summary

    Platelet activation, measured by beta-thromboglobulin (beta-tg), is present at rest in patients with coronary artery disease. This activation correlates with disease extent but is not affected by exercise-induced ischemia.

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    Area of Science:

    • Cardiology
    • Hematology
    • Clinical Medicine

    Background:

    • Platelet activation plays a role in atherothrombosis.
    • Beta-thromboglobulin (beta-tg) is a marker of in vivo platelet activation.

    Purpose of the Study:

    • To investigate in vivo platelet activation in patients with ischemic heart disease.
    • To determine the relationship between platelet activation, exercise, and coronary artery disease severity.

    Main Methods:

    • Maximal ECG treadmill exercise testing was performed on 26 normal subjects and 18 patients with ischemic heart disease.
    • Plasma beta-thromboglobulin (beta-tg) levels were measured pre- and post-exercise.
    • Coronary angiography was performed on 16 patients to assess coronary artery disease.

    Main Results:

    • Resting beta-tg levels were significantly higher in patients with ischemic heart disease compared to normal subjects (p < 0.05).
    • Beta-tg levels did not change significantly after exercise in either group.
    • Resting beta-tg levels positively correlated with the presence and extent of coronary artery disease (r = 0.53, p < 0.05).
    • Post-exercise beta-tg levels showed no correlation with exercise-induced ischemia.

    Conclusions:

    • In vivo platelet activation is present at rest in patients with coronary artery disease.
    • Resting platelet activation is related to the presence and extent of coronary artery disease.
    • Exercise-induced ischemia does not appear to acutely affect in vivo platelet activation markers like beta-tg.

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