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Macrophage function in senescence.

H Finger, B Heymer, C H Wirsing von König

    Gerontology
    |January 1, 1982
    PubMed
    Summary
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    Aged mice show better resistance to Listeria monocytogenes infection after dextran sulfate 500 administration compared to young adults. Pretreatment with Bordetella pertussis further enhanced this resistance, revealing significant phagocytic reserves in older animals.

    Area of Science:

    • Immunology
    • Gerontology
    • Microbiology

    Background:

    • Dextran sulfate 500 (DS 500) is known to induce immunosuppression.
    • Age-related changes in immune function can significantly impact host defense mechanisms.
    • Listeria monocytogenes infection is a model for studying bacterial pathogenesis and immune responses.

    Purpose of the Study:

    • To investigate the impact of dextran sulfate 500 on the immune response to Listeria monocytogenes in aged mice.
    • To compare the effects in aged mice versus young adult mice.
    • To explore potential interventions to restore immune function in aged mice.

    Main Methods:

    • Parenteral injection of dextran sulfate 500 (DS 500) into aged (22-month-old) and young adult (2- to 3-month-old) NMRI mice.

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  • Sublethal infection with Listeria monocytogenes (4.5 X 10(3) CFU).
  • Administration of heat-killed Bordetella pertussis organisms as a pretreatment in aged mice.

    • Main Results:

    • DS 500 administration led to a complete loss of resistance in young adult mice but had less dramatic consequences in aged mice.
    • Aged mice exhibited prolonged survival times and reduced Listeria counts in the spleen compared to young adults.
    • Pretreatment with Bordetella pertussis completely abolished the DS 500-induced loss of resistance in aged mice.

    Conclusions:

    • Aged mice possess a higher intrinsic phagocytic capacity compared to young adult mice.
    • Aged NMRI mice demonstrate significant reserves of phagocytic activity that can be mobilized.
    • These findings highlight age-dependent differences in immune response and the potential for immune modulation in older individuals.