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Bleomycin compatibility with selected intravenous medications.

R T Dorr, Y M Peng, D S Alberts

    Journal of Medicine
    |January 1, 1982
    PubMed
    Summary
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    Bleomycin is compatible with most parenteral drugs, including antibiotics and heparin. However, it is incompatible with certain antibiotics, chemotherapy agents like methotrexate, and vitamin C.

    Area of Science:

    • Oncology
    • Pharmacology
    • Clinical Pharmacy

    Background:

    • Parenteral medications are frequently co-administered in clinical settings.
    • Ensuring drug compatibility is crucial for patient safety and therapeutic efficacy.
    • Bleomycin is a widely used chemotherapeutic agent with specific administration requirements.

    Purpose of the Study:

    • To evaluate the in vitro compatibility of bleomycin with common parenteral medications.
    • To identify potential drug interactions and incompatibilities when preparing admixtures containing bleomycin.

    Main Methods:

    • In vitro admixture experiments were conducted using bleomycin and various parenteral drugs.
    • Bleomycin concentrations were determined using a radioimmunoassay procedure.
    • Compatibility was assessed based on the stability and integrity of bleomycin in admixture.

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    Main Results:

    • Bleomycin demonstrated compatibility with a majority of tested drugs, including aminoglycoside antibiotics, vinca alkaloid antineoplastics, fluorouracil, phosphate salt corticosteroids, diphenhydramine, and heparin sulfate.
    • Incompatible admixtures were identified with acidic cephalosporin and penicillin-derived antibiotics, methotrexate, mitomycin C, hydrocortisone sodium succinate, and ascorbic acid (vitamin C).

    Conclusions:

    • Bleomycin exhibits a favorable compatibility profile with many commonly used parenteral medications.
    • Clinicians should exercise caution and avoid co-administration of bleomycin with specific incompatible drugs, including certain antibiotics, antineoplastics, and vitamin C.