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Related Experiment Videos

Lymphoscintigraphy with Tc-99m-labeled dextran.

E Henze, H R Schelbert, J D Collins

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Technetium-99m dextran (TcDx) shows promise for lymphoscintigraphy, offering faster migration than current agents. This new tracer effectively visualizes lymphatic drainage and lymph nodes in both canine and human studies.

    Area of Science:

    • Nuclear Medicine
    • Radiopharmacology
    • Diagnostic Imaging

    Background:

    • Current lymphoscintigraphy agents face limitations due to slow tracer migration and uncertain phagocytosis effects.
    • These limitations impact the accuracy and efficiency of visualizing lymphatic pathways.

    Purpose of the Study:

    • To evaluate the efficacy of Technetium-99m dextran (TcDx) as a novel tracer for lymphoscintigraphy.
    • To assess TcDx migration, clearance, and imaging quality in preclinical and initial human studies.

    Main Methods:

    • Tc-99m dextran (110,000 MW) was injected interstitially in 13 dogs, with dynamic imaging and blood sampling.
    • Lymphatic drainage and node visualization were assessed, including in a canine model of lymphedema.
    • Initial human studies were conducted to evaluate lymphograms of the legs and pelvic/paraaortic nodes.

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    Main Results:

    • TcDx demonstrated clearance solely through lymphatic drainage, with rapid uptake in regional lymph nodes (knee/elbow: 12.4s, inguinal/axillary: 98.0s).
    • The tracer exhibited a clearance half-time of 31.5 minutes from the injection site.
    • In lymphedema, TcDx showed delayed migration, mirroring contrast lymphangiogram findings.
    • High-quality lymphograms were achieved in initial human studies.

    Conclusions:

    • TcDx exhibits favorable characteristics for lymphoscintigraphy, including predictable lymphatic clearance and efficient node visualization.
    • Its performance suggests it can overcome limitations of current colloidal tracers.
    • TcDx is a highly promising agent for advanced radionuclide lymphangiography.