Related Experiment Video

Updated: Aug 17, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Dipyridamole is an interferon inducer

A S Galabov, M Mastikova

    Acta Virologica
    |May 1, 1982
    PubMed

    Insights

    Dipyridamole, a compound, stimulates interferon production in various cells and in mice. This interferon, identified as IFN-alpha and IFN-beta, may explain dipyridamole's antiviral properties.

    Area of Science:

    • Immunology
    • Virology
    • Pharmacology

    Background:

    • Interferons (IFNs) are crucial cytokines in the innate immune response against viral infections.
    • Dipyridamole is a vasodilator with potential immunomodulatory effects.

    Purpose of the Study:

    • To investigate the capacity of dipyridamole to induce interferon production.
    • To characterize the type of interferon induced by dipyridamole.

    Main Methods:

    • In vitro induction of interferon using dipyridamole in mouse peritoneal leukocytes and non-lymphoid cell cultures (mouse L cells, human fibroblasts).
    • In vivo induction of interferon in mice following intravenous administration of dipyridamole.
    • Characterization of induced interferon based on pH stability, thermostability, and antigenic properties.

    Main Results:

    • Dipyridamole induced interferon production in vitro in mouse peritoneal leukocytes and, to a lesser extent, in mouse L cells and human diploid embryo lung fibroblasts.
    • Intravenous administration of dipyridamole induced interferon in mice, with peak levels dependent on dosage.
    • The induced interferon exhibited properties consistent with IFN-alpha and IFN-beta.

    Conclusions:

    • Dipyridamole possesses interferon-inducing capabilities.
    • The interferon induced by dipyridamole is characterized as IFN-alpha and IFN-beta.
    • This interferon-inducing property may underlie dipyridamole's broad-spectrum antiviral activity.

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