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Decrease in creatine kinase in human prostatic carcinoma compared to benign prostatic hyperplasia.

T G Pretlow, G B Whitehurst, T P Pretlow

    Cancer Research
    |November 1, 1982
    PubMed
    Summary
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    Prostate cancer tissue shows lower creatine kinase activity than benign hyperplasia tissue. This finding suggests creatine kinase may not be a universal marker for prostate cancer tumor burden.

    Area of Science:

    • Biochemistry
    • Oncology
    • Urology

    Background:

    • Elevated creatine kinase (CK) BB isoenzyme activity in peripheral blood has been observed in some prostate cancer patients.
    • CK activity is primarily localized to epithelial cells in both hyperplastic and cancerous prostate tissues.

    Purpose of the Study:

    • To compare creatine kinase activity levels in tissues from benign prostatic hyperplasia and prostate carcinoma.
    • To evaluate the potential of creatine kinase as a biomarker for prostate cancer tumor burden.

    Main Methods:

    • Analysis of creatine kinase activity in tissue samples from 22 patients with benign prostatic hyperplasia and 23 patients with prostate carcinoma.
    • Histochemical studies to confirm the cellular localization of creatine kinase activity.

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    Main Results:

    • Prostatic carcinomas exhibited significantly lower creatine kinase activity per gram of tissue compared to prostates with benign prostatic hyperplasia (p < 0.001).
    • Despite a larger epithelial component in carcinomas on average, epithelial cells in cancerous tissue contained less CK activity per cell than those in hyperplastic tissue.
    • The BB isoenzyme accounted for 98% of CK activity in both cancerous and non-cancerous prostate tissues.

    Conclusions:

    • Creatine kinase activity is lower in prostate cancer tissue than in benign hyperplastic tissue.
    • The significant variability in CK activity among different prostate carcinomas limits its utility as a general marker for tumor burden.
    • Longitudinal monitoring of individual patients may be necessary for creatine kinase to be useful in assessing prostate cancer tumor burden.