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[Human nonspecific killer cells].

H Thränhardt, F Zintl, J Milleck

    Folia Haematologica (Leipzig, Germany : 1928)
    |January 1, 1982
    PubMed
    Summary
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    Natural killer (NK) and K-cells exhibit distinct activities in human leukocytes, with NK-cells found in both T and non-T lymphocytes, while K-cells are non-T lymphocytes.

    Area of Science:

    • Immunology
    • Cell Biology
    • Hematology

    Context:

    • Investigates the cytotoxic activity of human Natural Killer (NK) cells and K-cells.
    • Compares these activities against K562 cell line and murine cells in Graffi erythroblast leukaemia.
    • Utilizes the 51Cr release assay for quantitative measurement of cell-mediated cytotoxicity.

    Purpose:

    • To identify and characterize NK and K-cells in various human tissues and blood fractions.
    • To determine the lineage and distribution of NK and K-cells within the immune system.
    • To assess the impact of acute leukaemia and chemotherapy on NK and K-cell activity.

    Summary:

    • NK and K-cells are present in human blood and bone marrow but absent in thymus, lymph nodes, and tonsils.
    • K-cells are identified as non-T lymphocytes, whereas NK-cells can be found in both T and non-T lymphocyte fractions.

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  • Leukemia cells rarely show NK or K-cell activity; chemotherapy reduces NK-cell activity in ALL patients in remission but not K-cell activity.

    • Impact:

    • Suggests NK and K-cells are similar but not identical cell populations.
    • Provides insights into immune cell dysfunction in acute leukaemia patients undergoing chemotherapy.
    • Highlights potential therapeutic targets by differentiating NK and K-cell roles in cytotoxic responses.