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Substance P-immunoreactive nerves in the human cornea and iris
Investigative Ophthalmology & Visual Science
|November 1, 1982
Summary
Substance P (SP) nerve fibers were found in the human cornea and iris. These SP-immunoreactive nerves are present in the corneal epithelium, stroma, and iris, particularly at the pupillary margin.
Area of Science:
- Ophthalmology
- Neuroscience
- Histology
Background:
- Substance P (SP) is a neuropeptide involved in pain and inflammation.
- The distribution and function of SP in ocular tissues are not fully understood.
Purpose of the Study:
- To investigate the presence and localization of Substance P (SP) in human corneas and irides.
Main Methods:
- Human corneal and iris tissues were obtained from surgical procedures.
- Indirect immunofluorescence technique was employed using a monoclonal SP antibody.
Main Results:
- SP immunofluorescence was detected in varicose nerve fibers within the corneal epithelium.
- Nerve trunks immunoreactive for SP were identified in the corneal stroma.
- SP-immunoreactive nerve fibers were predominantly found in the pupillary margin of the iris, in both dilator and sphincter muscles.
Conclusions:
- Substance P (SP) is present in the nerve fibers of the human cornea and iris.
- The findings suggest a potential role for SP in ocular sensory pathways and autonomic innervation of the iris.