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Related Experiment Videos

Histamine release by neuromuscular blocking agents in man.

J Moss, D M Philbin, C E Rosow

    Klinische Wochenschrift
    |September 1, 1982
    PubMed
    Summary

    Neuromuscular blocking agents can cause dose-dependent histamine release in humans, significantly impacting hemodynamics. Pretreatment and drug design can mitigate these adverse reactions.

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    Area of Science:

    • Pharmacology
    • Anesthesiology
    • Clinical Medicine

    Background:

    • Histamine release from neuromuscular blocking agents (NMBAs) is implicated in hemodynamic responses.
    • Understanding this histamine release is crucial for patient safety during anesthesia.

    Purpose of the Study:

    • To quantify plasma histamine levels after NMBA administration in humans.
    • To investigate strategies for attenuating adverse reactions associated with histamine release.
    • To validate the cat model for screening novel NMBAs.

    Main Methods:

    • Measurement of plasma histamine concentrations in human subjects following NMBA administration.
    • Evaluation of factors like administration rate, H1/H2 antagonist pretreatment, and drug design modifications.
    • Comparative analysis with data from a feline model.

    Main Results:

    • NMBA administration resulted in dose-dependent histamine release in humans.
    • Histamine release was demonstrated to be hemodynamically significant.
    • Pretreatment with H1/H2 antagonists and altered drug design showed potential in reducing adverse effects.
    • Human data supported the utility of the cat model for NMBA screening.

    Conclusions:

    • Neuromuscular blocking agents induce dose-dependent and hemodynamically significant histamine release in humans.
    • Clinical strategies such as pretreatment and drug modification can attenuate adverse reactions.
    • The cat model is a valid tool for preclinical screening of novel neuromuscular blocking agents.

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