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Summary
The Anton antigen, a blood group determinant, is serologically studied. It appears linked to the Lutheran blood group system through specific cell phenotypes, but is controlled by an independent gene.
Area of Science:
- Immunology
- Serology
- Genetics
Background:
- The Anton specificity refers to a particular antigenic determinant.
- Previous studies have suggested a potential association between Anton specificity and the Lutheran blood group system.
Purpose of the Study:
- To serologically characterize five antisera with Anton specificity.
- To elucidate the relationship between the Anton determinant and the Lutheran blood group system.
Main Methods:
- Serological analysis of five antisera.
- Enzyme treatment (trypsin) of red blood cells.
- Phenotyping of Lu(a-b-) cells.
Main Results:
- The Anton determinant is resistant to proteolytic enzyme treatment.
- The determinant is present on recessive Lu(a-b-) phenotype cells.
- Association with the dominant Lu(a-b-) phenotype is mediated by an independent gene, In(Lu).
Conclusions:
- The Anton antigen is not solely dependent on the Lutheran blood group locus.
- The In(Lu) gene, independent of the Lutheran locus, controls the expression of the dominant Lu(a-b-) phenotype relevant to Anton specificity.