[Therapy of advanced neuroblastoma in children]

The success rate of treatment for advanced neuroblastoma in childhood is still unsatisfactory. The Austrian pediatric oncology working group since 1979 uses a chemotherapy protocol of Dimethyl-triazeno-imidazol-carboxamid, Adriamycin, N-Lost, Vincristin or modified for age and stage a combination of Dimethyl-triazeno-imidazol-carboxamid, Adriamycin, N-Lost, Vincristin, Cyclophosphamide and Cis-platinum. Over a 30 month period 27 children with neuroblastoma were registered, six had a stage III, twelve a stage IV tumor. Currently 15 patients have no evidence of disease, six patients are alive with tumor, one patient with stage III and five patients with stage IV are dead.