[Pharmacodynamics and the pharmacokinetic parameters of etmozin in ventricular heart rhythm disorders]

A single dose of 300 mg of ethmosine per os has been found to exert an antiarrhythmic action 1-2 h after its administration in 60% of the patients and may be used to terminate episodes of ventricular arrhythmias. 3-4 h after the beginning of its administration, a complete antiarrhythmic effect was observed in giving a "loading" dose of 500-600 mg of ethmosine at the beginning of the treatment followed by maintenance therapy (200 mg given every 8 hours). To treat patients with ventricular rhythm disturbances, ethmosine may be used in a daily dose of 600-900 mg without side effects.