[Gastrointestinal hormone release in dumping symdrome before and after reconstruction of duodenal passage]

Serum gastrin, serum-GIP and serum insulin levels were measured before and after interposition operation (Henley-Soupault) in 10 patients with severe dumping-syndrome (PGS). The results were compared to those obtained in 10 normal subjects without any gastrointestinal disease. In the PGS pre-operative group there was a significantly lower serum gastrin concentration compared to normals, while the serum-GIP-concentration was significantly higher. After interposition operation all serum-hormone-levels tended towards normal values. There was no difference between the basal serum insulin levels of the three groups. The change in postprandial insulin release was parallel to the serum-GIP-levels. It is concluded that there is a close connection between disturbed release of gastrointestinal hormones and the dumping syndrome.