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Plasma inactive renin in patients with hyperthyroidism.

M Nakamaru, T Ogihara, J Higaki

    The Journal of Clinical Endocrinology and Metabolism
    |January 1, 1983
    PubMed
    Summary
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    In hyperthyroidism, active plasma renin activity (PRA) is elevated due to increased conversion of inactive renin. This conversion normalizes with treatment, suggesting sympathetic activity facilitates it.

    Area of Science:

    • Endocrinology
    • Cardiovascular Physiology

    Background:

    • Plasma renin activity (PRA) plays a crucial role in blood pressure regulation.
    • Hyperthyroidism is associated with cardiovascular changes, including potential alterations in the renin-angiotensin-aldosterone system.

    Purpose of the Study:

    • To investigate the levels and activity of active and inactive PRA in patients with hyperthyroidism.
    • To explore the relationship between thyroid hormone levels and PRA.
    • To assess the effect of normalizing thyroid function and beta-blockade on PRA.

    Main Methods:

    • Measurement of active and inactive PRA in 20 hyperthyroid patients and 16 controls.
    • Repeated measurements after achieving euthyroid state or after propranolol treatment.
    • Correlation analysis between PRA and serum thyroid hormone levels (T3, T4).

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    Main Results:

    • Active PRA was significantly higher in untreated hyperthyroid patients compared to controls.
    • Inactive PRA did not differ between groups.
    • Active PRA normalized upon achieving euthyroidism.
    • Propranolol treatment reduced active PRA.
    • A positive correlation was observed between the proportion of active PRA and serum T3/T4 levels.

    Conclusions:

    • Hyperthyroidism facilitates the in vivo conversion of inactive renin to active renin.
    • Increased sympathetic activity likely contributes to this enhanced conversion.
    • Thyroid hormone levels are correlated with the activation state of renin.