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Related Experiment Videos

[Dihydrotestosterone-binding characteristics in human prostatic adenoma].

Ts I Gerasimova, A N Smirnov, A F Buniatian

    Problemy Endokrinologii
    |September 1, 1982
    PubMed
    Summary

    Molecular characteristics of androgenic nuclear receptors in human prostate adenoma were identified. Dihydrotestosterone (DHT) binding in cytosol suggests it is primarily with testosterone-estradiol-binding globulin, not a specific DHT receptor for diagnostics.

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    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Urology

    Context:

    • Prostate adenoma is a common condition affecting men.
    • Understanding androgenic nuclear receptors is crucial for prostate cancer research.
    • Previous studies have focused on receptor localization and binding characteristics.

    Purpose:

    • To characterize the molecular properties of androgenic nuclear receptors in human prostate adenoma.
    • To compare dihydrotestosterone (DHT) binding in prostate adenoma cytosol and blood serum.
    • To determine the binding protein for DHT in prostate adenoma cytosol.

    Summary:

    • Molecular characteristics of androgenic nuclear receptors in human prostate adenoma were determined, including Stokes radius (2.3 nm), sedimentation coefficient (3.1 S), molecular weight (31,500 Da), and friction ratio (1.1).

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  • Receptors were predominantly found in nuclear fractions.
  • DHT binding in prostate adenoma cytosol was investigated and found to be primarily with testosterone-estradiol-binding globulin, not a specific cytosol receptor.

    • Impact:

    • This study clarifies the molecular nature of androgenic nuclear receptors in prostate adenoma.
    • Findings suggest that DHT binding in prostate cytosol is mediated by a known serum protein.
    • The results indicate that quantitative control of cytosol DHT receptors is not recommended for diagnostic purposes in prostate adenoma.