Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferons as antivirals in man.

T C Merigan

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |September 24, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Interferon therapy shows promise in preventing and treating viral infections like hepatitis B and herpesviruses. While effective, side effects such as fatigue and fever are common but reversible with dosage adjustments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nonviral interferon inducers.

    The Journal of general physiology·2009
    Same author

    Effect of therapeutic immunization with HIV type 1 recombinant glycoprotein 160 ImmunoAG vaccine in HIV-infected individuals with CD4+ T cell counts of >or=500 and 200-400/mm3 (AIDS Clinical Trials Group Study 246/946).

    AIDS research and human retroviruses·2001
    Same author

    Functional correlates of insertion mutations in the protease gene of human immunodeficiency virus type 1 isolates from patients.

    Journal of virology·2001
    Same author

    Variants other than aspartic acid at codon 69 of the human immunodeficiency virus type 1 reverse transcriptase gene affect susceptibility to nuleoside analogs.

    Antimicrobial agents and chemotherapy·2001
    Same author

    Anti-HIV type 1 activity of 3'-fluoro-3'-deoxythymidine for several different multidrug-resistant mutants.

    AIDS research and human retroviruses·2001
    Same author

    High degree of interlaboratory reproducibility of human immunodeficiency virus type 1 protease and reverse transcriptase sequencing of plasma samples from heavily treated patients.

    Journal of clinical microbiology·2001
    Same journal

    The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Natural microcosms in ecology: fulfilling the promise of model systems?

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    See all related articles

    Area of Science:

    • Immunology
    • Virology
    • Pharmacology

    Background:

    • Interferons are utilized for prophylaxis and treatment of viral infections.
    • Their primary role is prophylactic, acting on sites not yet affected by disease.
    • Effective in both acute and chronic viral conditions, including respiratory and herpesviral illnesses.

    Purpose of the Study:

    • To evaluate the prophylactic and therapeutic applications of interferons.
    • To assess the efficacy of interferons in suppressing Dane particles in chronic hepatitis B virus infection.
    • To characterize the side effects associated with different types of interferon.

    Main Methods:

    • Administration of interferons for prophylaxis and treatment of viral infections.
    • Dosage of 10(6) units or greater daily for Dane particle suppression in chronic hepatitis B.

    Related Experiment Videos

  • Assessment of side effects including febrile response, fatigue, malaise, marrow suppression, and hair growth inhibition.

    • Main Results:

    • Interferons demonstrate prophylactic effects against viral diseases.
    • Consistent Dane particle suppression achieved in chronic hepatitis B patients with adequate dosage.
    • Side effects observed with leucocyte-derived interferon are similar to those with lymphoblastoid and bacterial-derived interferons, even with higher specific activity.

    Conclusions:

    • Interferons are valuable agents for viral infection management.
    • Hepatitis B virus (HBV) infection can be managed with interferon therapy, potentially leading to eradication.
    • Newer interferon preparations (lymphoblastoid and bacterial-derived) share similar side effect profiles with older leucocyte-derived interferons.