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Interferon therapy in neoplastic diseases.

H Strander, S Einhorn

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |September 24, 1982
    PubMed
    Summary
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    Genetika·2002

    Interferon (IFN) alpha and beta show promise in treating various tumors, causing regression in some patients. Further research is needed to optimize IFN therapy and its combination with other cancer treatments.

    Area of Science:

    • Oncology
    • Immunology

    Background:

    • Interferon (IFN) preparations, including alpha, beta, and gamma, are utilized in cancer treatment.
    • Limited data exists on Interferon gamma's efficacy in tumor patients.
    • Interferon alpha and beta treatments have been administered globally, demonstrating potential anti-tumor effects and side effects.

    Purpose of the Study:

    • To review the application and outcomes of Interferon alpha (IFN-alpha) therapy in tumor patients at our institution.
    • To assess the anti-tumor effects of IFN-alpha on specific malignancies.

    Main Methods:

    • Retrospective analysis of patients treated with IFN-alpha over the past decade.
    • Documentation of tumor types and observed anti-tumor responses.

    Main Results:

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    • IFN-alpha therapy has shown anti-tumor effects in patients with juvenile laryngeal papillomatosis, Hodgkin's disease, myelomatosis, ovarian carcinoma, hypernephroma, and glioblastoma.
    • Observed tumor regression in individual patients treated with IFN-alpha and IFN-beta.

    Conclusions:

    • IFN-alpha has demonstrated efficacy against a range of tumors.
    • Further investigation is required to establish optimal IFN therapy protocols and comparative effectiveness against other cancer treatments.
    • Combination therapy involving IFN should be explored.