Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferon: pharmacokinetics and toxicity.

G M Scott

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |September 24, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development of an online, patient-centred decision aid for patients with oropharyngeal cancer in the transoral robotic surgery era.

    Current oncology (Toronto, Ont.)·2017
    Same author

    Securing an OTL-HNS residency: how competitive is it? Comparing medical student perceptions to actual Canadian statistics.

    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale·2017
    Same author

    Clinical aspects of cytomegalovirus antiviral resistance in solid organ transplant recipients.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2012
    Same author

    Viral factors influencing the outcome of human cytomegalovirus infection in liver transplant recipients.

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2011
    Same author

    Diversity of antiviral-resistant human cytomegalovirus in heart and lung transplant recipients.

    Transplant infectious disease : an official journal of the Transplantation Society·2010
    Same author

    The effect of extra vitamin B feeding on rats exposed to weak gamma radiation.

    The British journal of radiology·2010
    Same journal

    The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Natural microcosms in ecology: fulfilling the promise of model systems?

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    See all related articles

    Interferons are rapidly cleared from serum, with kidneys potentially being the primary site of destruction. Their therapeutic efficacy may depend more on stimulating host defenses than on serum levels.

    Area of Science:

    • Immunology
    • Pharmacology
    • Virology

    Background:

    • Interferons (IFNs) are crucial for antiviral defense but their rapid serum clearance and the relevance of serum levels to therapeutic activity remain unclear.
    • The kidney is implicated as a major site for interferon degradation.
    • Host defense stimulation by interferons may be more significant than circulating levels.

    Purpose of the Study:

    • To investigate the pharmacokinetic profile and therapeutic relevance of different interferon types.
    • To evaluate the relationship between interferon administration routes and serum antiviral activity.
    • To characterize the adverse effects and immunogenicity associated with exogenous interferon therapy.

    Main Methods:

    • Comparison of serum antiviral activity following intramuscular administration of fibroblast interferon versus leucocyte interferon.

    Related Experiment Videos

  • Administration of purified leucocyte and lymphoblastoid interferons to assess clinical and biochemical responses.
  • Monitoring for the development of neutralizing antibodies during interferon treatment.

    • Main Results:

    • Intramuscular injections of leucocyte interferon yield higher serum antiviral activity than fibroblast interferon at equivalent doses.
    • Leukocyte and lymphoblastoid interferons induce systemic reactions like fever and malaise, linked to corticosteroid and prostaglandin responses.
    • High doses of lymphoblastoid interferon can lead to liver damage and metabolic disturbances; neutralizing antibodies may develop with moderate doses.

    Conclusions:

    • Kidney plays a key role in interferon metabolism.
    • Therapeutic effects of interferons may be mediated by host defense stimulation rather than sustained serum concentrations.
    • Exogenous interferon administration requires careful monitoring due to potential adverse effects and immunogenicity.