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Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Do coronary collaterals influence the outcome of bypass graft surgery?
Insights
Coronary collateralization offers limited benefit for bypass grafting outcomes. Matched pair analysis showed no significant difference one year post-surgery, despite initial symptom relief in non-collateralized groups.
Area of Science:
- Cardiology
- Vascular Biology
- Surgical Outcomes
Background:
- Coronary collateralization plays a role in myocardial infarction.
- The impact of collateralization on coronary artery bypass grafting (CABG) outcomes requires further clarification.
Purpose of the Study:
- To evaluate the importance of coronary collateralization on bypass grafting outcomes.
- To determine if collateralization influences patient status one year after CABG.
Main Methods:
- A matched pair study was conducted using data from 814 patients.
- 143 matched pairs were formed, differing only in collateralization extent.
- Patients were recatheterized one year after bypass grafting.
Main Results:
- Collateralization provided some relief from resting symptoms pre-surgery.
- Collaterals were insufficient to meet pacing-induced stress demands.
- No significant differences were observed between groups one year post-CABG.
Conclusions:
- Coronary collateralization has a limited impact on long-term bypass grafting outcomes.
- While offering some pre-operative symptom relief, collateralization does not significantly alter post-CABG status.
- The perceived benefit in non-collateralized groups may be due to greater pre-operative symptoms.
Abstract:
The importance of coronary collateralization on the outcome of bypass grafting was evaluated in patients recatheterized one year after surgery. Because the severity of coronary artery disease correlated with the extent of collateralization, and ventricular function with previous myocardial infarction, we performed a matched pair study where differences in these variables were eliminated between pairs which differed only with respect to the extent of collateralization visualized during angiography. From a data bank of 814 operated patients, 143 matched pairs were formed. In the matched pair series of patients collaterals appear to provide some degree of additional blood flow to ischemic areas to allay resting symptoms before surgery, but collaterals are inadequate to meet the additional requirements of pacing-induced stress. The 2 groups were indistinguishable one year after bypass surgery. As the non-collateralized group was more symptomatic before surgery, it demonstrated greater subjective benefit from the procedure, however, this would be obscured in a consecutive series where collateralization generally correlates with severity of coronary artery disease.
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